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Brevital sodium

Generic Name: methohexital (METH oh HEX i tal)
Brand Name: Brevital Sodium
Physician reviewed Brevital Sodium patient information - includes Brevital Sodium description, dosage and directions.
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Drug Information:
Brevital Sodium is a barbiturate (bar-BIT-chur-ate). This medicine slows the activity of your brain and nervous system. Brevital Sodium is used to cause you to fall asleep before a surgery or other medical procedure. Brevital Sodium may also be used for purposes not listed in this medication guide. You should not use Brevital Sodium if you have a history of porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system). You should not use this medicine if you are allergic to Brevital Sodium or other barbiturates (butabarbital, pentobarbital, phenobarbital, and others), or if you have: Learn more

Brevital sodium Side Effects

Brevital Sodium Side Effects

Note: This document contains side effect information about methohexital. Some of the dosage forms listed on this page may not apply to the brand name Brevital Sodium.

For the Consumer

Applies to methohexital: injection solution reconstituted, intravenous solution prefilled syringe


  • You will be watched closely by your doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Very bad dizziness or passing out.
  • A fast heartbeat.
  • Feeling confused.
  • Trouble breathing, slow breathing, or shallow breathing.
  • Seizures.
  • Restlessness.
  • Anxiety.
  • This drug may cause tissue damage if the drug leaks from the vein. Tell your nurse if you have any redness, burning, pain, swelling, blisters, skin sores, or leaking of fluid where the drug is going into your body.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Upset stomach or throwing up.
  • Feeling sleepy.
  • Headache.
  • Hiccups.
  • Cough.
  • Twitching.
  • Belly pain.
  • Drooling.
  • Runny nose.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to methohexital: injectable powder for injection, intravenous powder for injection, intravenous solution


Frequency not reported: Circulatory depression, hypotension, tachycardia, peripheral vascular collapse, convulsions (associated with cardiorespiratory arrest)


Frequency not reported: Respiratory depression (including apnea), cardiorespiratory arrest, laryngospasm, bronchospasm, hiccups, dyspnea, rhinitis

Nervous system

Frequency not reported: Injury to nerves adjacent to injection site, seizure, headache


Frequency not reported: Emergence delirium, restlessness, and anxiety (especially in the presence of postoperative pain)


Frequency not reported: Nausea, vomiting, abdominal pain, salivation


Rare (less than 0.1%): Anaphylaxis


Frequency not reported: Liver function tests abnormal


Frequency not reported: Injection site pain


Frequency not reported: Thrombophlebitis


Frequency not reported: Skeletal muscle hyperactivity (twitching)


Frequency not reported: Erythema, pruritus, urticaria

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Brevital Sodium