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Generic Name: hydralazine and isosorbide dinitrate (hye DRAL a zeen and EYE soe SOR bide dye NYE trate)
Brand Names: BiDil
BiDil is used to treat heart failure. Learn about side effects, interactions and indications.
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Drug Information:
BiDil contains a combination of hydralazine and isosorbide dinitrate. Hydralazine is a vasodilator. It relaxes (widens) veins and arteries, which makes it easier for your heart to pump. Isosorbide dinitrate is in a group of drugs called nitrates. Isosorbide dinitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump. BiDil is used to treat heart failure in certain patients. BiDil may also be used for purposes not listed in this medication guide. Learn more

Bidil Side Effects

BiDil Side Effects

Note: This document contains side effect information about hydralazine / isosorbide dinitrate. Some of the dosage forms listed on this page may not apply to the brand name BiDil.

In Summary

Common side effects of BiDil include: dizziness, headache, and nausea. Other side effects include: hypotension, and paresthesia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to hydralazine/isosorbide dinitrate: oral tablet

Along with its needed effects, hydralazine / isosorbide dinitrate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydralazine / isosorbide dinitrate:

More common

  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • sweating
  • unusual tiredness or weakness

Less common

  • Fainting
  • fast, pounding, or irregular heartbeat or pulse

Incidence not known

  • Abdominal or stomach cramps or pain
  • black, tarry stools
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • chest pain or discomfort
  • dark urine
  • diarrhea
  • difficult or labored breathing
  • fever or chills
  • headache, severe and throbbing
  • joint pain
  • light-colored stools
  • lower back or side pain
  • mood or mental changes
  • muscle aches, cramps, or stiffness
  • pain in the arms or legs
  • painful or difficult urination
  • pale skin
  • shortness of breath
  • sores, ulcers, or white spots on the lips or inside the mouth
  • unusual behavior, such as disorientation to time or place, failure to recognize people, hyperactivity, or restlessness
  • unusual bruising or bleeding
  • unusual weight gain or loss
  • yellow eyes and skin

Some side effects of hydralazine / isosorbide dinitrate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Constipation
  • headache
  • nausea or vomiting

Less common

  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • cough
  • pain or tenderness around the eyes and cheekbones
  • stuffy or runny nose

Incidence not known

  • Change in urine color
  • continuing ringing, buzzing or other unexplained noise in the ears
  • feeling of constant movement of self or surroundings
  • feeling of warmth
  • inability to have or keep an erection
  • pinpoint red or purple spots on the skin
  • redness of the face, neck, arms and occasionally, upper chest
  • sensation of spinning
  • stomach soreness or discomfort

For Healthcare Professionals

Applies to hydralazine / isosorbide dinitrate: oral tablet


The most common side effects were headache, dizziness, asthenia, and nausea.

Nervous system

Very common (10% or more): Headache (50%), dizziness (32%)

Common (1% to 10%): Paresthesia

Postmarketing reports: Tinnitus, dysgeusia, hypoesthesia, migraine, syncope


Very common (10% or more): Asthenia (14%)

Postmarketing reports: Vertigo, facial pain, chest discomfort, chest pain, peripheral edema


Very common (10% or more): Nausea (10%)

Common (1% to 10%): Vomiting

Postmarketing reports: Abdominal discomfort, constipation


Common (1% to 10%): Hypotension, ventricular tachycardia

Postmarketing reports: Palpitations, flushing


Common (1% to 10%): Amblyopia

Postmarketing reports: Eyelid edema, vision blurred


Common (1% to 10%): Sinusitis

Postmarketing reports: Dyspnea


Postmarketing reports: Erythema, hyperhidrosis, pruritus, face swelling


Postmarketing reports: Chromaturia, erectile dysfunction


Postmarketing reports: Pain in extremity, myalgia


Postmarketing reports: Pulmonary renal syndrome

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Bidil