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Bicillin c-r

Generic Name: penicillin G benzathine and penicillin G procaine (PEN i SILL in G BEN za theen and PEN i SILL in G PRO kane)
Brand Name: Bicillin C-R, Bicillin C-R 900/300
Physician reviewed Bicillin C-R patient information - includes Bicillin C-R description, dosage and directions.
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Drug Information:
Bicillin C-R is a combination slow-onset antibiotic that is used to treat many types of severe infections caused by bacteria, including strep infections, pneumonia, and scarlet fever. Bicillin C-R may also be used for purposes not listed in this medication guide. You should not be treated with Bicillin C-R if you are allergic to penicillin or procaine. You should not be treated with this medicine if you are allergic to penicillin or procaine. Tell your doctor if you have ever had: an allergic reaction to a cephalosporin antibiotic (Keflex, Omnicef, and others); Learn more

Bicillin c-r Side Effects

Bicillin C-R Side Effects

Note: This document contains side effect information about penicillin g benzathine / procaine penicillin. Some of the dosage forms listed on this page may not apply to the brand name Bicillin C-R.

For the Consumer

Applies to penicillin g benzathine / procaine penicillin: intramuscular suspension

Warning

  • This drug is given as a shot into a muscle only. Very bad and sometimes deadly effects have happened when this drug was given into a vein or artery. Talk with the doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Signs of methemoglobinemia like a blue or gray color of the lips, nails, or skin; a heartbeat that does not feel normal; seizures; very bad dizziness or passing out; very bad headache; feeling very sleepy; feeling tired or weak; or shortness of breath. This effect is rare but may be deadly if it happens.
  • Fever, chills, or sore throat; any unexplained bruising or bleeding; or feeling very tired or weak.
  • Swelling.
  • Joint pain.
  • Very bad dizziness or passing out.
  • Area that feels hard, dark scab, lump, or very bad skin irritation where the shot was given.
  • Diarrhea is common with antibiotics. Rarely, a severe form called C diff–associated diarrhea (CDAD) may happen. Sometimes, this has led to a deadly bowel problem (colitis). CDAD may happen during or a few months after taking antibiotics. Call your doctor right away if you have stomach pain, cramps, or very loose, watery, or bloody stools. Check with your doctor before treating diarrhea.
  • Nerve damage can happen if this drug is given into or near a nerve. This could be long-lasting. Call your doctor right away if you have any numbness, tingling, or weakness.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Diarrhea.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to penicillin g benzathine/procaine penicillin: intramuscular suspension

Psychiatric

Hoigne's syndrome, characterized by various central nervous system symptoms (e.g., severe agitation with confusion, visual and auditory hallucinations, fear of impending death), has been reported after use of procaine penicillin, and less commonly, after use of this drug. Other symptoms associated with this syndrome have included psychosis, seizures, dizziness, tinnitus, cyanosis, palpitations, tachycardia, and abnormal taste perception.

Frequency not reported: Hoigne's syndrome (including severe agitation with confusion, visual and auditory hallucinations, fear of impending death, psychosis)

Parenteral Penicillin G Benzathine:

-Frequency not reported: Nervousness, confusion, anxiety, euphoria

Nervous system

Frequency not reported: Symptoms associated with Hoigne's syndrome (including seizures, dizziness, tinnitus, abnormal taste perception)

Parenteral Penicillin G:

-Frequency not reported: Neuropathy

Parenteral Penicillin G Benzathine:

-Frequency not reported: Headache, tremors, dizziness, somnolence, transverse myelitis, seizures, coma, vasovagal reaction, cerebrovascular accident, syncope

Cardiovascular

Frequency not reported: Symptoms associated with Hoigne's syndrome (including cyanosis, palpitations, tachycardia)

Parenteral Penicillin G Benzathine:

-Frequency not reported: Cardiac arrest, hypotension, tachycardia, palpitations, vasodilation

Hypersensitivity

Parenteral Penicillin G:

-Frequency not reported: Hypersensitivity reactions (including skin eruptions [maculopapular to exfoliative dermatitis], urticaria, laryngeal edema, fever, eosinophilia, other serum sickness-like reactions [including chills, fever, edema, arthralgia, prostration], anaphylaxis [including shock, death])

Parenteral Penicillin G Benzathine:

-Frequency not reported: Hypersensitivity reactions (including allergic vasculitis, pruritus, fatigue, asthenia, pain)

Gastrointestinal

Onset of pseudomembranous colitis symptoms have been reported during or after antibacterial therapy.

Parenteral Penicillin G:

-Frequency not reported: Clostridium difficile-associated diarrhea, pseudomembranous colitis

Parenteral Penicillin G Benzathine:

-Frequency not reported: Nausea, vomiting, blood in stool, intestinal necrosis

Renal

Parenteral Penicillin G:

-Frequency not reported: Nephropathy

Parenteral Penicillin G Benzathine:

-Frequency not reported: Elevated BUN, elevated creatinine, renal failure

Hematologic

Parenteral Penicillin G:

-Frequency not reported: Hemolytic anemia, leukopenia, thrombocytopenia

Parenteral Penicillin G Benzathine:

-Frequency not reported: Lymphadenopathy

Local

Parenteral Penicillin G Benzathine:

-Frequency not reported: Injection site reactions (including pain, inflammation, lump, abscess, necrosis, edema, hemorrhage, cellulitis, hypersensitivity, atrophy, ecchymosis, skin ulcer), neurovascular reactions (including warmth, vasospasm, pallor, mottling, gangrene, numbness of the extremities, cyanosis of the extremities, neurovascular damage)

Respiratory

Parenteral Penicillin G Benzathine:

-Frequency not reported: Hypoxia, apnea, dyspnea, pulmonary hypertension, pulmonary embolism

Hepatic

Parenteral Penicillin G Benzathine:

-Frequency not reported: Elevated AST

Musculoskeletal

Parenteral Penicillin G Benzathine:

-Frequency not reported: Joint disorder, periostitis, myoglobinuria, rhabdomyolysis, exacerbation of arthritis

Ocular

Parenteral Penicillin G Benzathine:

-Frequency not reported: Blurred vision, blindness

Genitourinary

Parenteral Penicillin G Benzathine:

-Frequency not reported: Neurogenic bladder, hematuria, proteinuria, impotence, priapism

Other

Parenteral Penicillin G Benzathine:

-Frequency not reported: Aggravation of existing disorder

Dermatologic

Parenteral Penicillin G Benzathine:

-Frequency not reported: Diaphoresis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Bicillin C-r