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Generic Name: rufinamide (roo FIN a mide)
Brand Names: Banzel
Banzel (rufinamide) is used in combination with other medications to treat adults and children with Lennox-Gastaut syndrome. Includes Banzel side effects, interactions and indications.
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Drug Information:
Banzel (rufinamide) is a seizure medication, also called an anti-epileptic or anticonvulsant. Banzel is used together with other medicines to treat seizures caused by Lennox-Gastaut syndrome, a severe form of childhood epilepsy that also causes developmental and behavior problems. Banzel is for use in adults and children who are at least 1 year old. You should not use Banzel if you have a severe liver disease, or a genetic heart rhythm disorder called "Short QT syndrome." Before taking Banzel, tell your doctor if you have heart disease, liver disease, kidney disease (or if you are on dialysis), or a history of depression, mental illness, or suicidal thoughts or actions. Learn more

Banzel Side Effects

Banzel Side Effects

Note: This document contains side effect information about rufinamide. Some of the dosage forms listed on this page may not apply to the brand name Banzel.

In Summary

Common side effects of Banzel include: seizure, dizziness, drowsiness, fatigue, headache, nausea, and vomiting. Other side effects include: status epilepticus, ataxia, blurred vision, diplopia, and skin rash. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to rufinamide: oral suspension, oral tablet

Along with its needed effects, rufinamide (the active ingredient contained in Banzel) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rufinamide:

More common

  • Dizziness
  • shakiness in the legs, arms, hands, or feet
  • sleepiness or unusual drowsiness
  • trembling or shaking of the hands or feet
  • uncontrolled eye movements

Less common

  • Attack, assault, or force
  • black, tarry stools
  • chest pain
  • chills
  • cough
  • cough producing mucus
  • diarrhea
  • difficult or painful urination
  • difficulty with breathing
  • dizziness or lightheadedness
  • fear or nervousness
  • feeling of constant movement of self or surroundings
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • pain or tenderness around the eyes and cheekbones
  • rash
  • restlessness
  • sensation of spinning
  • shakiness and unsteady walk
  • shivering
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stuffy or runny nose
  • sweating
  • swollen glands
  • tightness in the chest
  • trouble sitting still
  • trouble sleeping
  • trouble walking
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting


  • Bleeding gums
  • blood in the urine or stools
  • burning while urinating
  • fainting
  • frequent urination
  • inability to hold urine
  • increased urge to urinate during the night
  • increased volume of pale, dilute urine
  • lower back or side pain
  • pale skin
  • pinpoint red spots on the skin
  • pounding, slow heartbeat
  • sore tongue
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • troubled breathing with exertion
  • waking to urinate at night

Some side effects of rufinamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Blurred vision
  • double vision
  • seeing double

Less common

  • Acid or sour stomach
  • back pain
  • belching
  • change in hearing
  • decreased appetite
  • difficulty having a bowel movement (stool)
  • ear drainage
  • earache or pain in the ear
  • heartburn
  • indigestion
  • itching skin
  • stomach discomfort, upset, or pain
  • upper abdominal or stomach pain


  • Increased appetite

For Healthcare Professionals

Applies to rufinamide: oral suspension, oral tablet

Nervous system

Very common (10% or more): Somnolence, headache, dizziness

Common (1% to 10%): Status epilepticus, convulsion, abnormal coordination, nystagmus, psychomotor hyperactivity, tremor


The most commonly reported adverse reactions overall were headache, dizziness, fatigue, and somnolence.


Very common (10% or more): Nausea, vomiting

Common (1% to 10%): Upper abdominal pain, constipation, dyspepsia, diarrhea


Common (1% to 10%): Diplopia, blurred vision, nystagmus


Common (1% to 10%): Anxiety, insomnia

Frequency not reported: Suicidal behavior and ideation


Common (1% to 10%): Back pain


Very common (10% or more): Anemia

Uncommon (0.1% to 1%): Lymphadenopathy, leukopenia, neutropenia, iron deficiency anemia, thrombocytopenia


Common (1% to 10%): Anorexia, eating disorder, decreased appetite, weight loss


Uncommon (0.1% to 1%): Right bundle branch block, first degree atrioventricular block

Frequency not reported: QT shortening


Common (1% to 10%): Rash, acne


Common (1% to 10%): Oligomenorrhea


Uncommon (0.1% to 1%): Hepatic enzymes increased


Frequency not reported: Multi-organ sensitivity reactions


Common (1% to 10%): Pneumonia, influenza, nasopharyngitis, ear infection sinusitis, rhinitis


Very common (10% or more): Fatigue

Common (1% to 10%): Gait disturbance

Frequency not reported: Head injury, contusion


Common (1% to 10%): Epistaxis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Banzel