Note: This document contains side effect information about teriflunomide. Some of the dosage forms listed on this page may not apply to the brand name Aubagio.
Common side effects of Aubagio include: alopecia, decreased neutrophils, decreased white blood cell count, diarrhea, increased serum alanine aminotransferase, nausea, decreased platelet count, hyperkalemia, and lymphocytopenia. Other side effects include: cystitis, increased gamma-glutamyl transferase, neutropenia, hypertension, and viral gastroenteritis. See below for a comprehensive list of adverse effects.
Applies to teriflunomide: oral tablet
Oral route (Tablet)
Severe liver injury, including fatal liver failure, has been reported in patients receiving leflunomide, and a similar risk is expected with teriflunomide. Teriflunomide use is contraindicated in patients with severe hepatic impairment. Concomitant use with other hepatotoxic drugs may increase the risk of liver injury. Monitoring is recommended and discontinuation of therapy, including an accelerated elimination procedure, is advised if liver injury is suspected. Teriflunomide may cause major birth defects if used during pregnancy. Pregnancy must be excluded before starting treatment with teriflunomide. Teriflunomide is contraindicated in pregnant women or women of childbearing potential who are not using reliable contraception. Pregnancy must be avoided during teriflunomide treatment or prior to the completion of the drug elimination procedure after treatment; advise women to use reliable contraception. Discontinue teriflunomide and use an accelerated drug elimination procedure if pregnancy occurs.
Along with its needed effects, teriflunomide (the active ingredient contained in Aubagio) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking teriflunomide:
Some side effects of teriflunomide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to teriflunomide: oral tablet
The most commonly reported side effects were increased ALT, alopecia, diarrhea, influenza, nausea and paresthesia.
Common (1% to 10%): Neutropenia, leukopenia, decreased neutrophil count, decreased WBC count
Uncommon (0.1% to 1%): Anemia, mild thrombocytopenia, lymphopenia
Frequency not reported: Decreased platelet count
Very common (10% or more): Increased ALT levels (up to 14%)
Common (1% to 10%): Increased AST and GGT levels
Frequency not reported: Fatal liver failure and dysfunction, hepatotoxicity
Common (1% to 10%): Hypertension, palpitations, tachycardia
Very common (10% or more): Alopecia (up to 13%)
Common (1% to 10%): Acne, pruritus, tinea pedis, rash
Uncommon (0.1% to 1%): Generalized pruritus
Frequency not reported: Stevens-Johnson syndrome, toxic epidermal necrolysis
Very common (10% or more): Diarrhea (Up to 18%), nausea (up to 14%)
Common (1% to 10%): Upper abdominal pain, toothache, tooth infection, oral herpes, viral gastroenteritis, abdominal distention, vomiting, inguinal hernia
Very rare (less than 0.01%): Pancreatitis
Very common (10% or more): Urinary tract infection
Common (1% to 10%): Cystitis, menorrhagia
Very common (10% or more): Influenza
Common (1% to 10%): Seasonal allergy, oral herpes, mild allergic reactions
Frequency not reported: Bone marrow effects/Immunosuppression potential/Infections
Very common (10% or more): Hypophosphatemia
Common (1% to 10%): Decreased weight, hyperkalemia
Uncommon (0.1% to 1%): Hyperamylasemia
Common (1% to 10%): Musculoskeletal pain, myalgia
Very common (10% or more): Headache (up to 22%), paresthesia (up to 10%)
Common (1% to 10%): Sciatica, burning sensation, carpal tunnel syndrome, peripheral neuropathy (both polyneuropathy and mononeuropathy), multiple sclerosis, neuralgia, hyperesthesia
Uncommon (0.1% to 1%): Dysgeusia
Common (1% to 10%): Blurred vision, conjunctivitis
Common (1% to 10%): Anxiety, depression
Very common (10% or more): Influenza (up to 12%)
Common (1% to 10%): Upper respiratory infection, lower respiratory tract infection, bronchitis, sinusitis, laryngitis, pharyngitis
Very rare (less than 0.01%): Interstitial lung disease
Common (1% to 10%): Transient acute renal failure, pollakiuria
Uncommon (0.1% to 1%): Increased blood creatinine
Common (1% to 10%): Pain
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Aubagio