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Generic Name: dalfampridine (dal FAM pri deen)
Brand Names: Ampyra
Ampyra (dalfampridine) is used to improve walking in patients with multiple sclerosis. Includes Ampyra side effects, interactions and indications.
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Drug Information:
Ampyra (dalfampridine) is a potassium channel blocker. Ampyra is a prescription medicine used to improve walking in adults with multiple sclerosis (MS). It is not known if Ampyra is safe or effective in children less than 18 years old. Ampyra can cause a seizure (convulsions), even if you have never had one before. Taking too much dalfampridine may increase your risk of seizure. Kidney problems may also increase your risk. Your kidney function may need to be tested before you start taking this medicine. Learn more

Ampyra Side Effects

Ampyra Side Effects

Note: This document contains side effect information about dalfampridine. Some of the dosage forms listed on this page may not apply to the brand name Ampyra.

In Summary

Common side effects of Ampyra include: urinary tract infection. Other side effects include: balance impairment, insomnia, and nausea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dalfampridine: oral tablet extended release

Along with its needed effects, dalfampridine (the active ingredient contained in Ampyra) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dalfampridine:

More common

  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain

Less common

  • Blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • difficulty controlling your bladder or bowels
  • difficulty walking
  • feeling sad or depressed
  • forgetful
  • muscle cramps
  • problems with swallowing
  • slurred speech
  • unusual tiredness or weakness

Incidence not known

  • Cough
  • dizziness
  • fast heartbeat
  • hives, itching, skin rash
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • tightness in the chest

Get emergency help immediately if any of the following symptoms of overdose occur while taking dalfampridine:

Symptoms of overdose

  • Confusion
  • epileptic seizure that will not stop
  • increased sweating
  • memory loss
  • reduced awareness
  • seizures
  • weakness

Some side effects of dalfampridine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Headache
  • lack or loss of strength
  • nausea
  • trouble sleeping

Less common

  • Back pain
  • constipation
  • fever
  • muscle aches
  • sore throat
  • stuffy or runny nose

For Healthcare Professionals

Applies to dalfampridine: oral tablet extended release

Nervous system

Common (1% to 10%): Dizziness, headache, balance disorder, multiple sclerosis relapse, paresthesia, tremor

Uncommon (0.1% to 1%): Seizure, exacerbation of trigeminal neuralgia


Common (1% to 10%): Nausea, constipation, dyspepsia

Postmarketing reports: Vomiting


Common (1% to 10%): Back pain


Common (1% to 10%): Nasopharyngitis, pharyngolaryngeal pain, dyspnea


Very common (10% or more): Urinary tract infection (12%)


Uncommon (0.1% to 1%): Anaphylaxis, angioedema, hypersensitivity


Common (1% to 10%): Insomnia, anxiety


Common (1% to 10%): Asthenia

Uncommon (0.1% to 1%): Chest discomfort


Common (1% to 10%): Palpitations


Uncommon (0.1% to 1%): Rash, urticaria

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Ampyra