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Alunbrig

Generic Name: brigatinib (bri GAT i nib)
Brand Names: Alunbrig
Alunbrig (brigatinib) is used to treat anaplastic lymphoma kinase-positive (ALK+) metastatic non-small cell lung cancer. Includes Alunbrig side effects, interactions and indications.
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Drug Information:
Alunbrig (brigatinib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Alunbrig is used to treat non-small cell lung cancer that has spread to other parts of the body (metastatic), when treatment with other cancer medicine has not been successful. Alunbrig is used only if your cancer has a specific genetic marker (an abnormal "ALK" gene). Your doctor will test you for this gene. Alunbrig can cause serious side effects such as lung problems, vision problems, high blood pressure, high blood sugar, very slow heartbeats, muscle damage, or pancreatitis. Learn more

Alunbrig Side Effects

Alunbrig Side Effects

Note: This document contains side effect information about brigatinib. Some of the dosage forms listed on this page may not apply to the brand name Alunbrig.

In Summary

Common side effects of Alunbrig include: asthenia, blurred vision, cough, decreased visual acuity, diplopia, dyspnea, hyperglycemia, hypertension, increased amylase, increased creatine phosphokinase in blood specimen, increased serum lipase, myalgia, and visual disturbance. Other side effects include: interstitial pulmonary disease, pneumonitis, and bradycardia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to brigatinib: oral tablet

Along with its needed effects, brigatinib (the active ingredient contained in Alunbrig) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brigatinib:

More common

  • Abdominal or stomach pain or tenderness
  • back pain
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or tightness
  • chills
  • confusion
  • cough
  • decreased appetite
  • difficulty in moving
  • dizziness
  • fever
  • flushed, dry skin
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • joint pain
  • loss of appetite
  • muscle pain, tenderness, or weakness
  • nausea and vomiting
  • nervousness
  • pain in the arms or legs
  • pounding in the ears
  • skin rash or itching
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • swollen joints
  • thickening of bronchial secretions
  • trouble breathing
  • unusual tiredness or weakness
  • weakness in the arms, hands, legs, or feet

Some side effects of brigatinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Blurred vision or changes in vision
  • decreased appetite
  • diarrhea
  • difficulty having a bowel movement (stool)
  • trouble sleeping

For Healthcare Professionals

Applies to brigatinib: oral tablet

General

-The most common adverse reactions (25% or more) were nausea, diarrhea, fatigue, cough, and headache.

-Serious adverse reactions occurred in 38% to 40% of patients; fatal cases were reported in 3.7% of patients and consisted of pneumonia (2 patients), sudden death, dyspnea, respiratory failure, pulmonary embolism, bacterial meningitis, and urosepsis (1 patient each).

Hepatic

Very common (10% or more): Increased AST (65%), increased ALT (40%), increased alkaline phosphatase (29%)

Endocrine

Very common (10% or more): Hyperglycemia (49%)

Musculoskeletal

Very common (10% or more): Increased creatine phosphokinase (48%), muscle spasms (17%), back pain (15%), myalgia/musculoskeletal pain (15%), arthralgia (14%), pain in extremity (11%)

Gastrointestinal

Very common (10% or more): Increased lipase (45%), nausea (40%), increased amylase (39%), diarrhea (38%), vomiting (24%), constipation (19%), abdominal pain and distension/epigastric discomfort (17%)

Hematologic

Very common (10% or more): Anemia (40%), lymphopenia (27%)

Other

Very common (10% or more): Fatigue/asthenia (36%), pyrexia (14%)

Respiratory

Very common (10% or more): Cough (34%), dyspnea/exertional dyspnea (27%)

Common (1% to 10%): interstitial lung disease/pneumonitis, hypoxia

Nervous system

Very common (10% or more): Headache/sinus headache (28%), peripheral sensory neuropathy/paresthesia (13%)

Dermatologic

Very common (10% or more): Rash (exfoliative, pruritic, pustular)/acneiform dermatitis (24%)

Metabolic

Very common (10% or more): Decreased phosphorous (23%), decreased appetite (22%)

Cardiovascular

Very common (10% or more): Prolonged activated partial thromboplastin time (22%), hypertension (21%)

Common (1% to 10%): Bradycardia

Psychiatric

Very common (10% or more): Insomnia (11%)

Ocular

Very common (10% or more): Visual disturbance (10%), pneumonia (10%)

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Alunbrig