Note: This document contains side effect information about anagrelide. Some of the dosage forms listed on this page may not apply to the brand name Agrylin.
Common side effects of Agrylin include: abdominal pain, dizziness, headache, nausea, and palpitations. Other side effects include: back pain, fever, tachycardia, vomiting, and anorexia. See below for a comprehensive list of adverse effects.
Applies to anagrelide: oral capsule
Along with its needed effects, anagrelide (the active ingredient contained in Agrylin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking anagrelide:
Incidence not known
Some side effects of anagrelide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to anagrelide: oral capsule
Very common (10% or more): Headache (43.5%), asthenia (23.1%), dizziness (15.4%), pain (15%)
Common (1% to 10%): Fever
Frequency not reported: Migraine, syncope, somnolence, confusion, insomnia, nervousness, amnesia
Very common (10% or more): Palpitations (26.1%)
Common (1% to 10%): Chest pain, tachycardia
Frequency not reported: Arrhythmia, cardiovascular disease, angina pectoris, heart failure, postural hypotension, thrombosis, vasodilation
Postmarketing reports: Torsades de pointes, ventricular tachycardia
Very common (10% or more): Diarrhea (25.7%), nausea (17.1%), abdominal pain (16.4%), flatulence (10.2%)
Common (1% to 10%): Vomiting, anorexia, dyspepsia, constipation, gastritis, aphthous stomatitis, pharyngitis, hemorrhage, eructation, dehydration
Very common (10% or more): Edema (20.6%)
Common (1% to 10%): Peripheral edema
Frequency not reported: Tinnitus, flu symptoms, chills
Frequency not reported: Anemia, thrombocytopenia, ecchymosis, lymphadenopathy
Very rare (less than 0.01%): Cholestatic liver failure
Frequency not reported: Elevated liver enzymes
Common (1% to 10%): Back pain
Frequency not reported: Arthralgia, myalgia, leg cramps
Very common (10% or more): Dyspnea (11.9%)
Frequency not reported: Pharyngitis, cough, rhinitis, epistaxis, respiratory disease, sinusitis, pneumonia, bronchitis, pleural effusion, pulmonary hypertension, pulmonary infiltrates, asthma, allergic alveolitis
Common (1% to 10%): Rash (including urticaria)
Frequency not reported: Skin disease, alopecia, pruritus
Frequency not reported: Photosensitivity, amblyopia, abnormal vision, visual field abnormality, diplopia
A 30-year-old man developed erectile dysfunction after 2 months of treatment with anagrelide (the active ingredient contained in Agrylin) which disappeared 2 weeks after stopping the drug. A definitive cause could not be determined.
Frequency not reported: Dysuria, hematuria
Very rare (less than 0.01%): A 60-year-old woman developed shortness of breath, palpitations, and chest pain after 1 week of treatment leading to respiratory failure and intubation by week 5. Patient recovered after treatment with methylprednisolone.
Frequency not reported: Severe hypersensitivity pneumonitis
The authors of the case report of severe hypersensitivity pneumonitis suggest that patients receiving anagrelide therapy, alone or in combination with hydroxyurea, may benefit from monitoring with serial chest X-rays, pulmonary function testing, and echocardiography to detect the development of cardiomyopathy or hypersensitivity pneumonitis.
Postmarketing reports: Tubulointerstitial nephritis.
Frequency not reported: Depression
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Agrylin