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Acetadote is used to treat acetaminophen overdose. Includes Acetadote side effects, interactions and indications.
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Drug Information:
Acetadote (acetylcysteine) injection will be used in an emergency room setting to prevent or lessen potential liver damage resulting from an overdose of acetaminophen, the leading cause of drug toxicity in the United States. According to the FDA, more than 56,000 emergency room visits and 100 deaths occur each year due to unintentional overdoses of acetaminophen, a common ingredient in many over-the-counter painkillers. Acetadote, administered intravenously within 8 to 10 hours after ingestion of a potentially hepatotoxic quantity of acetaminophen, is indicated to prevent or lessen hepatic injury. Learn more

Acetadote Side Effects

Acetadote Side Effects

Note: This document contains side effect information about acetylcysteine. Some of the dosage forms listed on this page may not apply to the brand name Acetadote.

For the Consumer

Applies to acetylcysteine: oral capsule, oral powder, oral solution, oral tablet effervescent

Other dosage forms:

  • inhalation solution
  • intravenous solution

Along with its needed effects, acetylcysteine (the active ingredient contained in Acetadote) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking acetylcysteine:

Incidence not known

  • Difficulty with breathing or swallowing
  • fever
  • hives or itching
  • nausea
  • rash with or without a fever
  • reddening of the skin, especially around the ears
  • severe or ongoing vomiting
  • swelling of the eyes, face, or inside of the nose
  • unusual tiredness or weakness

Some side effects of acetylcysteine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Mild nausea
  • stomach upset
  • vomiting

For Healthcare Professionals

Applies to acetylcysteine: compounding powder, inhalation solution, intravenous solution, oral capsule, oral tablet, oral tablet effervescent


The most common adverse events were anaphylactoid reaction, nausea, vomiting, flushing, and skin rash.


Anaphylactoid symptoms include airway obstruction (bronchospasm), angioedema, dyspnea, hypotension, shock, tachycardia, urticaria, and injection site reaction (including rash). These are most common either during, or at the end of the loading dose infusion, and may be dose related. Careful monitoring is recommended.

Very common (10% or more): Anaphylactoid reaction (18%)

Uncommon (0.1% to 1%): Anaphylaxis

Rare (less than 0.1%): Acquired sensitization

Frequency not reported: Dermal eruptions


Very common (10% or more): Vomiting NOS (12%)

Common (1% to 10%): Nausea

Frequency not reported: Stomatitis


Common (1% to 10%): Respiratory symptoms, pharyngitis, rhinorrhea, rhonchi, throat tightness

Frequency not reported: Bronchoconstriction, bronchospasm, irritation to tracheal and bronchial tract (inhalation route), hemoptysis, dyspnea, respiratory arrest, coughing, stridor

Respiratory symptoms were defined as presence of any of the following: cough, wheezing, stridor, shortness of breath, chest tightness, respiratory distress, or bronchospasm.


Common (1% to 10%): Tachycardia

Uncommon (0.1% to 1%): Hypotension

Frequency not reported: Cyanosis, tachycardia, bradycardia, cardiac arrest, extrasystoles, flushing, hypertension, vasodilation, ECG changes


Common (1% to 10%): Urticaria/facial flushing, rash NOS, pruritus, flushing

Frequency not reported: Angioedema, sweating, edema periorbital, clamminess


Common (1% to 10%): Edema

Frequency not reported: Acidosis, hypokalemia


Rare (less than 0.1%): Death

Frequency not reported: Fever, malaise, rigors, chest pain, facial pain, facial edema, raised temperature

Nervous system

Frequency not reported: Syncope, generalized seizure, drowsiness


Frequency not reported: Injection site reaction


Frequency not reported: Arthralgia, arthropathy


Frequency not reported: Deterioration of liver function


Frequency not reported: Thrombocytopenia


Frequency not reported: Blurred vision, eye pain, puffy eyes, itching/redness/irritation in eyes (ophthalmic formulation)


Frequency not reported: Anxiety

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Acetadote